This article is a call to action for nurses to critically reflect on their ability to enhance their proficiency in cultivating successful nurse-patient relationships while upholding the necessary boundaries inherent in their professional roles. In rehabilitation, the nurse-patient relationship is meaningful and transformative, potentially impacting patient outcomes significantly. This paper delves into three fundamental elements of nursing in rehabilitation. First, the concept of rehabilitation is explored, highlighting the role of nurses as not just carers but as catalysts for transformation and emphasising the potential of relationships in facilitating change. Second, underscoring the centrality of the nurse-patient relationship and its crucial role in enhancing the patient’s rehabilitation journey, establishing, utilising, maintaining, and modifying effective relationships, fostering patient motivation, and inspiring hope, is discussed. Healthcare professionals, particularly rehabilitation nurses, are not just responsible for promoting these relationships but are the cornerstone of successful rehabilitation. The quality of these relationships can significantly influence the patient’s recovery and well-being, pointing to the significance of the nurse’s role as essential and integral to the patient’s rehabilitation journey. Upholding professional boundaries in these relationships is a critical responsibility that nurses must take seriously, as it ensures the ethical and practical delivery of care.