Diminished ovarian reserve (DOR) is defined as the reduced number of oocytes in the ovary. Loss of oocytes as women age is a normal transition towards natural menopause; however, the number of antral follicles present in young women and the rate of oocyte loss over reproductive life can vary, with some women having significantly fewer oocytes as early as age 30 years. In young women with DOR, the proportion of high quality oocytes is higher than in older women with DOR but lower than in young women with normal ovarian reserve. Risk factors for DOR include smoking, a history of unexplained infertility, a family history of premature menopause and previous chemotherapy or radiotherapy.
Implications of DOR include both reproductive and physical risk factors. For example, DOR is associated with an early menopause, and increased risks of osteoporosis, cardiovascular disease and distress, especially due to permanent infertility and unexpected changes of personal identity. In addition, because many couples delay their child-bearing years until a later stage of their reproductive life, DOR leading to early menopause can directly affect women’s reproductive potential. Furthermore, DOR is associated with a poor ovarian response in stimulation cycles of assisted reproductive technology (ART), and the quality of oocytes and health of pregnancies and babies remains controversial.
There are no medical treatments to directly increase ovarian oocyte quality, count, nor delay diminishing ovarian reserve. Instead, ART treatments focus on the use of procedures such as IVF and ICSI, egg freezing and donation. Studies have shown that dietary patterns may influence the age of natural menopause. Reduced dietary intake of fruit and carotenoids for example was a significant predictor of earlier onset of natural menopause and, as such, diet and other naturopathic interventions should also be considered as possible contributing factors in managing DOR. In addition, in Australia, women attempting to conceive are significantly more likely to seek complementary medicine (CM) including acupuncture and naturopathy compared to women who are not. As such, this article explores the case for research into the efficacy of naturopathy for treatment of women with DOR.