The relationship between a patient’s selenium (Se) intake, status and health has been described as complex. Through selenoproteins, Se can have a positive impact on human health by contributing to the body’s antioxidant system. However, Se can build up in plasma, binding to non-specific Se-containing proteins which, over time, may actually induce oxidative stress. Therefore, having an understanding of the relationship between Se and health, although complex, will aid the practitioner in connecting the dots between this nutrient and each patient’s unique health context.
In a healthcare setting, plasma Se is a validated, short-term marker reflecting a person’s recent Se intake. However, plasma Se may be influenced by a range of factors, including test-related (e.g., diurnal variation), physiological (e.g., gender) and behavioural (e.g., exercise), which may confound test accuracy. A thorough review of the research on this topic provides us with a clear understanding regarding ideal collection conditions and, together with a review of correlational studies linking plasma Se levels to a range of health effects and factors, strengthens clinicians’ interpretation of such results. Furthermore, the review substantiates an ideal plasma Se for Australian populations to be ≈1.60–1.90µmol/L, which is higher than the current reference range of 0.75–1.35µmol/L.